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document E1 Mechanism of Elimination
E1 indicates an elimination, unimolecular reaction, where rate = k [R-LG]. This implies that the rate-determining step of the mechanism depends on the decomposition of a single molecular species.   Overall, this pathway is a multi-step process with the following two critical steps:...
01 Aug, 2011 Comments: 0
document Elimination Reactions
Elimination reactions are important as a method for the preparation of alkenes. The term "elimination" describes the fact that a small molecule is lost during the process. A 1,2-elimination indicates that the atoms that are lost come from adjacent C atoms. The two most important methods...
01 Aug, 2011 Comments: 0
document Zaitsev Rule
In many cases elimination reactions may proceed to give alkenes that are isomeric but with one formed in excess of the other (i.e. a major product). Zaitsev's Rule, based on experimental observations of the dehydration of alcohols, expresses the preference for eliminations to give the highly...
01 Aug, 2011 Comments: 0
document Dehydrohalogenation of Alkenes
The dehydration of alkyl halides is considered a 1,2- or β-elimination and follows the general reaction scheme:   When heated with strong bases, alkyl halides typically undergo 1,2-elimination reactions to generate alkenes. Typical bases are NaOH or KOH or NaOR or KOR (alkoxide)...
22 Jul, 2011 Comments: 0
document E2 Mechanism of Elimination
E2 indicates an elimination, bimolecular reaction, where rate = k [B][R-LG]. This implies that the rate-determining step involves an interaction between these two species, the base B, and the organic substrate, R-LG   This pathway is a...
01 Aug, 2011 Comments: 0
document Leaving Groups
 A leaving group , LG, is an atom (or a group of atoms) that is displaced as stable species taking with it the electrons in the bond that were connecting it to the rest of the molecule. Typically the leaving group is an anion (e.g. Cl-) or a neutral molecule...
13 May, 2012 Comments: 0
document Nucleophilicity versus Basicity
Nucleophilicity and basicity are very similar properties in that species that are nucleophiles are usually also bases (e.g. HO- , RO-).  However, some nucleophiles are poor bases and some bases are poor nucleophiles.  Bases are predominantly defined by the pKa of...
16 Aug, 2012 Comments: 0

Department of Chemistry & Chemical Biology