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document Nucleophilic Substitution Reactions
Nucleophilic substitution reactions are an important class of reactions that allow the interconversion of functional groups.  The general scheme can be seen below, however the mechanism (electron pathway) is dependent upon the structure of the starting material and nucleophile.  A wide...
01 Aug, 2011 Comments: 0
document Thermodynamics of Nucleophilic Substitutions
Multi-step reactions have intermediates (I) and multiple transition states (TS). Remember, a transition state is the theoretical energy maxima where bonds are being made and broken, usually shown by dashed lines in Lewis structures.  An intermediate, though not the final product, is typically...
07 Mar, 2011 Comments: 0
document SN2 Mechanism of Nucleophilic Substitution
SN2 indicates a substitution, nucleophilic, bimolecular reaction, described by the kinetic expression: rate = k [Nu][R-LG].  The transition state in the rate determining step involves both the nucleophile and molecule with the leaving group.   This pathway is a concerted...
22 Jul, 2011 Comments: 0
document SN1 Mechanism of Nucleophilic Substitution
SN1 indicates a substitution, nucleophilic, unimolecular reaction, described by the kinetic expression: rate = k [R-LG].  This means, the concentration of the nucleophile is not significant in increasing the reaction rate because it is not a part of the rate determining step. ...
22 Jul, 2011 Comments: 0

Department of Chemistry & Chemical Biology